Aldo-Keto Reductases

A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.

Also Known As:

Aldo-Keto Reductase; Aldo-Keto Reductase Family; Aldo-Keto Reductase Superfamily; Aldo Keto Reductase; Aldo Keto Reductase Family; Aldo Keto Reductase Superfamily; Aldo Keto Reductases; Reductase, Aldo-Keto; Reductases, Aldo-Keto

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Alcohol Oxidoreductases: 57
      - Carbohydrate Dehydrogenases
        Sugar Alcohol Dehydrogenases
        Aldo-Keto Reductases: 315
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Aldo-Keto Reductases: 315

Frederike Gossner Selected Research

Frederike Gossner Research Topics

Disease

Drug/Important Bio-Agent (IBA)